Ervatamin-C (Tabernaemontana divaricata)

From ConceptWiki

•  Also known as

  Term	Synonym scope	Preferred in	Community	Swiss-Prot
  Ervatamin-C	broad synonym
  Ervatamin-C (Tabernaemontana divaricata)	exact synonym	life sciences
  ERVC_TABDI	exact synonym
  ERV-C

•  Functional information

  Connection	Element	Community	Swiss-Prot
  performs	EC 3.4.22.-
  gene product has molecular function	lysosomal cysteine-type endopeptidase
  has function	Cysteine proteinase. Hydrolyzes denatured natural substrates such as casein, hemoglobin, azoalbumin and azocasein with a high specific activity. Has little or no activity against synthetic substrates.
  enzyme regulation by	Activated by thio-specific activators such as cysteine, beta-mercaptoethanol, DTT and glutathione. Inhibited by the thiol-specific inhibitors leupeptin, iodoacetamide, PCMB, NEM, mercuric chloride and sodium tetrathionate.

•  Localization and spatial information

  Connection	Element	Community	Swiss-Prot
  occurs in	Tabernaemontana divaricata
  gene product expressed in tissue	Laticifer.
  has subcellular localization	Secreted.

•  Structural and physical information

  Connection	Element	Community	Swiss-Prot
  component of	Monomer.
  has mass spectrometry data	23000.0 is the determined molecular weight; MALDI is the ionization method; 1-208 is the part of the protein sequence entry that corresponds to the molecular weight;

•  Pharmaceutical information

  Connection	Element	Community	Swiss-Prot
  has biophysicochemical properties	Kinetic parameters:(KM=9.09 uM for azoalbumin; ); pH dependence: Optimum pH is 7.5-8.0 with azoalbumin or hemoglobin as substrate. Active and stable from pH 2.0 to 12.0; temperature dependence: Optimum temperature is 50 degrees Celsius with azoalbumin as substrate. Thermostable up to 70 degrees Celsius;

•  Conceptual and other information

  Connection	Element	Community	Swiss-Prot
  gene product plays role in biological process	Proteolysis
  similarity confers association with	peptidase C1 family

•  Reference information

  Connection	Element	Identifier	Community	Swiss-Prot
  source	Swiss-Prot	P83654

•  Tags

  Tag	Community	Swiss-Prot
  amino acid, peptide, or protein
  Ervatamin-C

•  Pointers to Ervatamin-C (Tabernaemontana divaricata)

  Other concept	Connection	Concept	Community
  Sampa Biswas	has interest	Ervatamin-C (Tabernaemontana divaricata)
  Chandana Chakrabarti	has interest	Ervatamin-C (Tabernaemontana divaricata)
  Sibani Chakraborty	has interest	Ervatamin-C (Tabernaemontana divaricata)
  Jiban K Dattagupta	has interest	Ervatamin-C (Tabernaemontana divaricata)
  Medicherla V Jagannadham	has interest	Ervatamin-C (Tabernaemontana divaricata)
  Monica Sundd	has interest	Ervatamin-C (Tabernaemontana divaricata)
  Piyali Guha G Thakurta	has interest	Ervatamin-C (Tabernaemontana divaricata)

•  Information in other websites

  P83654 in Swiss-Prot

  P83654 in Concept Web